So, I cannot tell you why...yet. But I can tell you that “something” has changed in Internet Explorer that is effecting (or is it affecting) many of the SharePoint implementations I have done. Maybe it is a recent IE Service Pack, I honestly don't know. But I noticed about three weeks ago that a portal that I visit all the time was centered. I also noticed that the “Modify Shared Page” link did not work either.
After a little testing I discovered that the only difference between my “normal” portals and the centered one was that I did not have the centered portal in my TRUSTED SITES list. As soon as I added the portal URL everything aligned properly and the menu began working.
Recently I have been contacted by coworkers and clients with the same issue on many portals so I thought I would create this post to see who else is having this problem, or better have somebody tell me that it is a service pack issue.
Now if I can just figure out why the search box does this from time to time...